货号：AG678

品牌：Merck Millipore

规格：

目录价：￥3208.00

市场价格：￥2726.80

会员价格：￥2566.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Connexin 43, control peptide for MAB3067 View All» Trade Name: Chemicon (Millipore) View All» Qty/Pk: 100 µg View All» Product Overview: Control peptide for Chemicon Catalog Number MAB3067 (Mouse anti-connexin 43). Peptide corresponds to a 19 amino acid sequence within the C-terminal cytoplasmic domain (aa252-270) of Mouse Cx43 (2). This sequence is identical in rat and bovine. Mouse Connexin 43 is a 382 amino acid gap junction protein with a predicted M.W. of ~43 kDa. View All» Key Applications: Peptide Inhibition Assay View All» Application Notes: ELISA Optimal working dilutions must be determined by end user. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. View All» UniProt Summary: FUNCTION: SwissProt: P17302 # One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.SIZE: 382 amino acids; 43008 Da SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts with SGSM3.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.TISSUE SPECIFICITY: Expressed in the heart and fetal cochlea.DISEASE: SwissProt: P17302 # Defects in GJA1 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD) [MIM:164200]; also known as oculodentoosseous dysplasia. ODDD is a highly penetrant syndrome presenting with craniofacial (ocular, nasal, dental) and limb dysmorphisms, spastic paraplegia, and neurodegeneration. Craniofacial anomalies tipically include a thin nose with hypoplastic alae nasi, small anteverted nares, prominent columnella, and microcephaly. Brittle nails and hair abnormalities of hypotrichosis and slow growth are present. Ocular defects include microphthalmia, microcornea, cataracts, glaucoma, and optic atrophy. Syndactyly type III and conductive deafness can occur in some cases. Cardiac abnormalities are observed in rare instances. & Defects in GJA1 may be the cause of syndactyly type III (SDTY3) [MIM:186100]. Syndactyly is an autosomal dominant trait and is the most common congenital anomaly of the hand or foot. It is marked by persistence of the webbing between adjacent digits, so they are more or less completely attached. In this type there is usually complete and bilateral syndactyly between the fourth and fifth fingers. Usually it is soft tissue syndactyly but occasionally the distal phalanges are fused. The fifth finger is short with absent or rudimentary middle phalanx. The feet are not affected. & Defects in GJA1 a the cause of hypoplastic left heart syndrome (HLHS) [MIM:241550]. HLHS refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood flow from the left ventricular outflow tract. In addition, the syndrome includes underdevelopment of the left ventricle, aorta, and aortic arch, as well as mitral atresia or stenosis.SIMILARITY: SwissProt: P17302 ## Belongs to the connexin family. Alpha-type (group II) subfamily. View All» Species: Mouse View All» Brand Family: Chemicon View All» Presentation: Supplied as 1 mg/mL solution in PBS, pH 7.4, containing no preservatives. View All» UniProt Number: P17302 View All» Storage Conditions: Store at -20°C in undiluted aliquots. Avoid repeated freeze-thaw cycles. View All» Gene Symbol:

• GJA1

• GJAL

• Cx43

• DFNB38

• SDTY3

• CX43

• ODD

• ODDD

• ODOD

• Connexin-43
  View All» Product Name: Connexin 43, control peptide for MAB3067 View All» Entrez Gene Number: NM_000165.3 View All»
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