货号：AG903

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MMP-11 View All» Trade Name: Chemicon (Millipore) View All» Qty/Pk: 250 µL View All» Product Overview: AG903 is a concentrated serum free culture media from human tumor cells treated with Interleukin-1. the media contains human stromelysin-3 (MMP-11), as well as other MMPs and TIMPs. View All» Key Applications: Positive Control View All» Application Notes: For use in Western blotting applications and in substrate zymography. The product contains variable amounts of the MMP-11, and is intended as a qualitative positive control. No attempt has been made to quantify the amount of MMP-11 in the product. A sample volume of 20-40 μl is sufficient for Western blots. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. View All» UniProt Summary: FUNCTION: SwissProt: P24347 # May play an important role in the progression of epithelial malignancies.COFACTOR: Binds 1 calcium ion per subunit (By similarity). & Binds 2 zinc ions per subunit (By similarity).SIZE: 488 amino acids; 54618 Da TISSUE SPECIFICITY: Specifically expressed in stromal cells of breast carcinomas.DOMAIN: SwissProt: P24347 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: The precursor is cleaved by a furin endopeptidase (By similarity).SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Species: Human View All» Brand Family: Chemicon View All» Presentation: Concentrated culture media. Contains no preservative. View All» Storage Conditions: Aliquot and store at -20º C. Avoid repeated freeze/thaw cycles. View All» Gene Symbol:

• MMP11

• ST3

• SL-3

• MMP-11

• STMY3

• EC 3.4.24.-
  View All» Product Name: MMP-11 View All» Alternate Names: Stromelysin-3 View All» UniProt Number: P24347 View All» Entrez Gene Number: NM_005940.3 View All»
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