金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: PAR1 Long Name: Protease-Activated Receptor 1 Aliases: Cf2r; F2R; HTR; ThrR; TRGPC Entrez Gene IDs: 2149 (Human); 14062 (Mouse); 25439 (Rat) Background: PAR1 Human Proteinase-Activated Receptor 1 (hPAR1), also known as thrombin receptor, is a 65-70 kDa, 399 amino acid long member of the seven-transmembrane superfamily of cell-surface G protein-coupled receptors. PAR1 is activated by thrombin cleavage of its N-terminal propeptide in the extracellular domain. Human PAR1 is widely expressed in many cell types including endothelial cells, and it has been implicated in a variety of inflammatory responses. Over the regions used as immunogen, human and mouse PAR1 proteins are 58% identical in the region spanning the propeptide and extracellular domains, and 84% identical in the cytoplasmic tail.