金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Protein S/PROS1 Aliases: PROS1 Entrez Gene IDs: 5627 (Human); 19128 (Mouse); 81750 (Rat) Background: Protein S/PROS1 The PROS1 gene encodes Protein S, a ~70 kDa vitamin-K dependent plasma glycoprotein mainly synthesized by human hepatocytes. Protein S is a non-enzymatic cofactor in the degradation of coagulation factors Va and VIIIa and thus plays an anticoagulant role. Approximately 60% of Protein S circulates in complex with C4b-binding protein. Free Protein S is a mixture of monomers and multimers. The 652 aa Protein S proprotein is heavily modified with 11 carboxyglutamates, one hydroxyaspartate, disulfides and glycosylation. Human Protein S shows 80% aa identity with mouse Protein S.