金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: FKBP51 Long Name: 51 kDa FK506 Binding Protein Aliases: Dit1; FKBP5; FKBP54; Ptg-10 Entrez Gene IDs: 2289 (Human); 14229 (Mouse); 361810 (Rat) Background: FKBP51

FK506 binding protein, 51 kDa molecular weight (FKBP51) is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans- proline residues critical for proper folding of proteins. The macrolide immunosuppressants FK506 and Rapamycin are FKBP51 inhibitors. FKBP51 levels are induced by glucocorticoids. It associates with HSP90 complexes that are critical for the proper folding of steroid receptors. Single nucleotide polymorphisms in FKBP51 have been associated with major depression and hyper-responsiveness to antidepressants.