金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: BACE-2 Long Name: beta-site Ayloid Precursor Protein Cleaving Enzyme 2 Entrez Gene IDs: 25825 (Human); 56175 (Mouse); 288227 (Rat) Background: BACEs Both BACE-1 and BACE-2 are membrane-bound aspartic proteases of the pepsin family. BACE-1 is a potential target for treatment of Alzheimer's disease because it is the principle b-secretase responsible for cleavage of amyloid precursor protein (APP). BACE-2 differs from BACE-1 in several aspects including pro-enzyme activation, substrate binding sites, transcriptional regulation, and function in A beta peptide production.