金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: BNIP3 Long Name: BCL2/Adenovirus E1B 19 Kda Protein-Interacting Protein 3-Like Aliases: Nip3 Entrez Gene IDs: 664 (Human); 12176 (Mouse); 84480 (Rat) Background: BNIP3 BNIP3 and its closely related functional homolog, BNIP3L, are proapoptotic mitochondrial proteins that are regulated by HIF-1 alpha. Each of these contains a single Bcl-2 homology 3 (BH3) domain and a C-terminal transmembrane domain required for mitochondrial localization, homodimerization, and regulation of its proapoptotic function. The mechanism of BNIP3-mediated apoptosis is independent of caspase activation and cytochrome c release.