金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: PKC beta 2 Long Name: Protein Kinase C beta 2 Entrez Gene IDs: 5579 (Human); 18751 (Mouse); 25023 (Rat) Background: PKC beta 2 Members of the Protein Kinase C (PKC) family are serine/threonine protein kinases that play a key regulatory role in a number of cellular functions including cell growth and differentiation, hormone secretion, and gene expression. Multiple genes and alternative splicing result in three subfamilies, which differ in their co-factor requirements: conventional PKC isoforms (alpha, beta 1, beta 2, and gamma) which require calcium and phosphatidylserine (PS), diacylglycerol (DAG) or phorbol esters for activation; novel isoforms (delta, epsilon, eta, and theta), which are calcium-independent but are still regulated by PS, DAG, or phorbol esters; and atypical isoforms (iota/lambda and zeta), which are calcium-independent and do not require PS, DAG, or phorbol esters for activation. PKC beta 2 regulation of c-myc expression has been shown to suppress insulin gene transcription in pancreatic beta-cells implicating PKC beta 2 for some of the beta-cell glucose toxicity found in diabetes.