货号：AP512

品牌：Merck Millipore

规格：500Ug

目录价：￥3015.00

市场价格：￥2562.75

会员价格：￥2412.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Sheep anti-Human IgM, (Fc) Antibody | AP512 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody reacts with human IgM, (Fc) as demonstrated by ELISA. View All» Molecular Weight: 50 kDa calculated View All» Epitope: IgM, (Fc) View All» Immunogen: Human anti-Human IgM (myeloma) Fc5u fragment View All» Background Information: Immunoglobin M (IgM) antibody is prominent in early immune responses to most antigens and is the predominant response in certain antibody responses such as "natural" blood group antibodies. IgM is the major immunoglobin expressed on surface B lymphocytes. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. No reactivity with IgG or IgA. May react with IgM of other species with low specificity. View All» Control: Human IgG, Human IgG Fab Fragment, Human IgG Fc, Human IgM Fc, Human IgM (myeloma) Fab m fragment, Human IgA, Mouse IgM, Rat IgM whole molecule, Chicken IgM whole molecule, Goat IgM whole molecule, Guinea Pig IgM whole molecule, Hamster IgM whole molecule, and Rabbit IgM whole molecule View All» Quality Assurance: Evaluated by ELISA against Human IgG, Human IgG Fab Fragment, Human IgG Fc, Human IgM Fc, Human IgM (myeloma) Fab m fragment, Human IgA, Mouse IgM, Rat IgM whole molecule, Chicken IgM whole molecule, Goat IgM whole molecule, Guinea Pig IgM whole molecule, Hamster IgM whole molecule, and Rabbit IgM whole molecule.ELISA Analysis: A representative lot detected Sheep Anti-Human IgM, (Fc) in ELISA. View All» Purification Method: Depletion View All» Presentation: Purified sheep polyclonal in PBS containing 0.05% sodium azide. Depleted against rabbit IgM and human IgG. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P01871 View All» Gene Symbol: IGHM View All» Alternate Names: Ig mu chain C region View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: ELISA View All» UniProt Summary: FUNCTION: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as an homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. SUBUNIT STRUCTURE: Immunoglobulin (Ig) molecules consist of two chains, one heavy chain (which can be alpha, delta, epsilon, gamma or mu) and one light chain (which can be kappa or lambda) each consisting of a variable and a constant region. An IgM molecule contains thus a mu heavy chain combined with either a kappa or a lambda light chains. It is found almost exclusively as an homopentamer in the serum. Membrane-bound IgM molecules are non-covalently associated with heterodimer of CD79A and CD79B.SUBCELLULAR LOCATION: Isoform 1: Secreted. Note: During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM.Isoform 2: Cell membrane; Single-pass type I membrane protein. POLYMORPHISM: All 4 combinations of the S/G and V/G polymorphisms at positions 191 and 215 have been observed in human mu chains.INVOLVEMENT IN DISEASE: Defects in IGHM are the cause of agammaglobulinemia type 1 (AGM1) [MIM:601495]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. Ref.10SEQUENCE CAUTION: The sequence CAA33071.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA34971.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. View All» Product Name: Sheep anti-Human IgM, (Fc) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 500 μg View All» Format: Purified View All» Host: Sheep View All»