金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Aminopeptidase O/ONPEP Aliases: APO; C90RF3; C9orf3; ONPEP Entrez Gene IDs: 84909 (Human); 72061 (Mouse); 290963 (Rat) Background: Aminopeptidase O/ONPEP Aminopeptidase O (AP-O; also C9orf3) is a 93 kDa (predicted), intracellular member of the M1 metalloprotease family of enzymes. It is expressed in heart, testis and pancreas where it cleaves N-terminal Arg and Asn residues. Human AP-O is 819 amino acids in length. Aminopeptidase O contains one catalytic domain (aa 167 - 589) with a zinc-binding site (His479 - His483) and a C-terminal ARM region (aa 706 - 819). At least three additional isoforms of Aminopeptidase O exist. Full-length human AP-O is 76% aa identical to mouse AP-O.