R&D Systems代理MAB4836 Human mGluR1 MAb (Clone 511622) (100 UG)

2025-06-27

货号:MAB4836

品牌:R&D Systems

规格:100ug

目录价:¥3720.00

市场价格:¥2976.00

会员价格:¥2976.00

  • 到货时间:3~4周

    金山科研平台,产品价格货期咨询微信:jinshanbio Molecule Information: mGluR1a Long Name: Metabotropic Glutamate Receptor 1 Aliases: GPRC1A; GRM1 Entrez Gene IDs: 2911 (Human); 14816 (Mouse); 24414 (Rat) Background: mGluR1a

    View mGluR1a IHC images. Metabotropic glutamate receptor 1 (mGluR1) is a 130 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. On neurons, mGluR1 is postsynaptic, associates with Gq-like proteins, mobilizes intracellular Ca++, and influences ion channel activity. Mature mGluR1 is 1176 amino acids (aa) in length and contains a 574 aa N-terminal extracellular domain (ECD) (aa 19-592). The ECD binds glutamate and forms either a covalent homodimer or heterodimer with CaSR. There is one alternative splice form for human mGluR1 that shows a 20 aa substitution for the C-terminal 308 amino acids. Over aa 33-522, human mGluR1 shares more that 98% aa identity with mouse, rat and canine mGluR1.

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