金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Orexin R2/HCRTR2 Long Name: Hypocretin Receptor Type 2 Aliases: HCRTR2; Orexin Receptor 2; OX2R Entrez Gene IDs: 3062 (Human); 387285 (Mouse); 25605 (Rat) Background: HCRTR2 View HCRTR2 IHC images. Hypocretin receptor 2 (HCRTR2); also known as orexin receptor 2 or OX2R is a 40 kDa 7-transmembrane G-protein-coupled glycoprotein that is a high affinity receptor for orexins A and B (hypocretins 1 and 2). In mouse brain, engagement of HCRTRs promotes wakefulness, such that absence of either orexins or their receptors creates a narcolepsy-like state. HCRTR2 also influences reward circuits involving food or addictive drugs. The extracellular portions of human HCRTR2 share 92% and 93% aa identity with corresponding portions of mouse and rat HCRTR2, respectively.