金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: HHV8-ORF74 Long Name: Human Herpesvirus 8 ORF74 Aliases: KSHV-vGPCR Entrez Gene IDs: 4961460 (Viral) Background: HHV8-ORF74 HHV8-ORF74 is a 342 amino acid viral 7-transmembrane receptor encoded by the Kaposi's sarcoma-associated herpesvirus 8. The G-protein-coupled receptor is a constitutively active homologue of CXCR2, the CXCL8 receptor (IL-8 RB). It contributes to Kaposi's sarcoma by triggering expression of paracrine factors such as VEGF-A, inflammatory cytokines, adhesion molecules and chemokines, and enhancing cell growth.