金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: MAG/Siglec-4a Long Name: Myelin-associated Glycoprotein Aliases: Siglec-4a Entrez Gene IDs: 4099 (Human); 29409 (Rat) Background: MAG / Siglec 4a

MAG exists as two isoforms which differ in the sequence and length of the cytoplasmic tail. The large form (71 kDa) and small form (67 kDa) arise from alternatively spliced mRNAs. Although MAG might encounter hemapoietic cells and lymphocytes under pathologic conditions, it would normally be expected to interact with neuronal cells. It has been shown that MAG promotes axonal growth from neonatal dorsal root ganglion (DRG) neurons and embryonic spinal neurons, but is a potent inhibitor of axonal re-growth from adult DRG and postnatal cerebellar neurons. MAG plays an important role in the interaction between axons and myelin. A soluble form of MAG containing the extracellular domain is released from myelin in large quantities and identified in normal human tissues and in tissues from patients with neurological disorders. This soluble MAG might contribute to the lack of CNS neuron regeneration after injury.