R&D Systems代理MAB563 Mouse IL-1 RII MAb (Clone 130817) (500 UG)-试剂-金山科研平台

R&D Systems代理MAB563 Mouse IL-1 RII MAb (Clone 130817) (500 UG)

2025-06-28

货号：MAB563

品牌：R&D Systems

规格：500ug

目录价：￥5070.00

市场价格：￥4056.00

会员价格：￥4056.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: IL-1 RII Long Name: Interleukin 1 Receptor II Aliases: CD121b; IL-1 R beta; IL1R2 Entrez Gene IDs: 7850 (Human); 16178 (Mouse) Background: IL-1 RII

View IL-1 RII IHC images. Two distinct types of receptors that bind the pleiotropic cytokines IL-1 alpha and IL-1 beta have been described. The IL-1 receptor Type I is an 80 kDa transmembrane protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. IL-1 receptor Type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and, endothelial cells. Both receptors are members of the immunoglobulin superfamily and show approximately 28% sequence similarity in their extracellular domains. The two receptor types do not heterodimerize in a receptor complex.

IL-1 RII has a short cytoplasmic domain and does not transduce IL-1 signals. In addition to the membrane-bound form of IL-1 RII, a naturally-occurring soluble form of IL-1 RII has been described. It has been suggested that the Type II receptor, either as the membrane-bound or as the soluble form, serves as a decoy for IL-1 and inhibits IL-1 action by blocking the binding of IL-1 to the signaling Type I receptor complex. Recombinant IL-1 soluble receptor type II is a potent antagonist of IL-1 action.

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