金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: SOCS-3 Long Name: Suppressor Of Cytokine Signaling 3 Aliases: ATOD4; CIS3; Cish3; SSI-3 Entrez Gene IDs: 9021 (Human); 12702 (Mouse); 89829 (Rat) Background: SOCS Family SOCS (suppressor of cytokine signaling) proteins, also called CIS (cytokine-inducible SH2-domain containing) proteins, are a family of eight adaptor molecules active in signaling pathways that regulate innate and adaptive immune responses. All SOCS contain a single SH2 domain and a SOCS box, which recruits E3 ubiquitin ligase complexes, thus enhancing destruction of the molecules bound by SOCS proteins. SOCS proteins influence macrophage and dendritic cell activation and are essential for T cell development and differentiation.