R&D Systems代理MAB58551 Human VAP-B MAb (Clone 736904) (100 UG)-试剂-金山科研平台

R&D Systems代理MAB58551 Human VAP-B MAb (Clone 736904) (100 UG)

2025-06-27

货号：MAB58551

品牌：R&D Systems

规格：100ug

目录价：￥3720.00

市场价格：￥2976.00

会员价格：￥2976.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: VAP-B Long Name: VAMP [Vesicle-associated Membrane Protein]-associated Protein B and C Aliases: ALS8; VAMP-B; VAMP-C; VAP-C Entrez Gene IDs: 9217 (Human); 56491 (Mouse); 60431 (Rat) Background: VAP-B

View VAP-B IHC images. VAP-B (vesicle-associated membrane protein (VAMP)-associated protein B) is a ubiquitously expressed type IV transmembrane protein belonging to the VAP family. It is found in ER, Golgi and other membranes as a homodimer or a heterodimer with VAP-A. VAPs recruit FFAT proteins that mediate many of their effects on regulation of membrane transport, phospholipid biosynthesis, microtubule organization, and the unfolded protein response. VAPs also interact with some SNARE and viral proteins, notably hepatitis C virus (HCV), which requires VAB-B for its propagation. The P56S polymorphism of VAP-B is found in amylotrophic lateral sclerosis and causes formation of intracellular aggregates and increased ER-stress-induced death of motor neurons. It can also promote cleavage and secretion of soluble VAP-B, which can then function as a ligand for EPH receptors.

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