金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: NLRP3/NALP3 Long Name: NLR Family, Pyrin Domain Containing 2 Aliases: AGTAVPRL; AII; AVP; CIAS1; Cryopyrin; FCAS; FCU; MWS; NACHT; NALP3; PYPAF1 Entrez Gene IDs: 114548 (Human); 216799 (Mouse); 287362 (Rat) Background: NALP3 NALP3 (NAcht Leucine-rich repeat Protein 3), also known as CIAS1, PYPAF or Cryopyrin is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NALP3 activates caspases 1 and 5. Defects in NALP3 may cause FCAS1, CINCA, or Muckle-Wells autoinflammatory syndromes.