金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Skp2 Long Name: S Phase Kinase-associated Protein 2 Aliases: FBL1; FBXL1; p45skp2 Entrez Gene IDs: 6502 (Human); 27401 (Mouse); 294790 (Rat) Background: Skp2 SKP2 (S-phase kinase-associated protein 2) is a 45-47 kDa cyclin A- and CDK2-associated phosphoprotein within the FBXL (F-box/LRR) family of ubiquitin ligases, designated FBXL1. As a component of the SCF (SKP1-Cul1-F-box) complex, SKP2 phosphorylation is required for degradation of CDK inhibitors such as p27/Kip1 and progression from G1 to S phases of the cell cycle. Deregulation in cancer promotes cell cycle progression and cancer growth.