金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: ARK5 Long Name: AMPK-related Protein Kinase 5 Aliases: NUAK1 Entrez Gene IDs: 9891 (Human); 77976 (Mouse); 299694 (Rat) Background: ARK5 AMPK-related kinase 5 (ARK5), also known as NUAK1, is a 74 kDa intracellular Ser/Thr kinase that promotes cell survival during nutrient deprivation and TNF family ligand-induced apoptosis. ARK5 is activated by Akt, NDR2, and LKB1-mediated phosphorylation at multiple serine and threonine residues. It inhibits the activation of Caspase-6, Caspase-8, and myosin phosphatases but promotes the activation of MMP2 and MMP9. ARK5 overexpression in several cancers contributes to increased tumor progression and aggressiveness. ARK5 contains one catalytic domain (aa 65-306), and a short isoform of the human protein is prematurely truncated within this domain.