金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Helios Long Name: DNA-binding Protein Helios Aliases: IKZF2; ZNF1A2; ZNFN1A2 Entrez Gene IDs: 22807 (Human); 22779 (Mouse) Background: Helios Helios, also known as IKZF2, is a 70 kDa DNA-binding transcription regulator in the Ikaros family that contains four N-terminal C2H2-type zinc finger domains and two C-terminal zinc finger domains. Helios is expressed in developing hematopoietic and epithelial tissues and in adult T cells and thymic-derived regulatory T cells (Treg). It forms homodimers and also heterodimers with other Ikaros family proteins Ikaros, Pegasus, Eos, and Aiolos. Alternate splicing of human Helios generates a short isoform that lacks three of the the N-terminal zinc finger domains. This isoform is overexpressed in T cell leukemias where it can still dimerize with Ikaros proteins but functions as a dominant negative regulator.