金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: RIP3 Long Name: Receptor Interacting Protein 3 Aliases: RIPK3 Entrez Gene IDs: 11035 (Human); 56532 (Mouse); 246240 (Rat) Background: RIP3 RIP3 (Receptor-Interacting Protein 3), also known as RIPK3, is a 518 amino acid (aa), 60 kDa phosphoprotein that contains an N-terminal protein kinase domain and a C-terminal interaction motif with which it binds RIP1. It converts cell response to TNF-alpha from apoptosis (RIP1 via Fas) to programmed necrosis (RIP1/RIP3) by inducing reactive oxygen species production. Alternately spliced human beta (252 aa) and gamma (231 aa) isoforms diverge after aa 219 and 221, respectively, and are found to antagonize RIP3.