R&D Systems代理MAB818 Human cIAP-1 (HIAP-2) MAb (Clone 681732) (100 UG)-试剂-金山科研平台

R&D Systems代理MAB818 Human cIAP-1 (HIAP-2) MAb (Clone 681732) (100 UG)

2025-06-28

货号：MAB818

品牌：R&D Systems

规格：100ug

目录价：￥3870.00

市场价格：￥3096.00

会员价格：￥3096.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: cIAP-1/HIAP-2 Long Name: Cellular Inhibitor of Apoptosis Protein 1 Aliases: BIRC2; HIAP-2; MIHB Entrez Gene IDs: 329 (Human); 11797 (Mouse) Background: cIAP-2/HIAP-1

View cIAP-1/HIAP-2 IHC images.Cellular inhibitor of apoptosis protein1 (cIAP-1, also known as BIRC2, MIHB, and HIAP2) and 2 (cIAP-2, also known as BIRC3, MIHC, and HIAP1), are members of the inhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. Structurally, cIAP-1 and cIAP-2 are each comprised of 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). Human cIAP-1 and cIAP-2 share 70% sequence identity. Functionally, cIAPs inhibit caspases through the direct interaction of its BIR domain with the active caspase. The ring finger domain of cIAP-1 and cIAP-2 also functions as an E3 ubiquitin ligase to ubiqutinylate specific target proteins. Caspase activity may be restored by mitochondrial proteins, such as SMAC/Diablo or HtrA2/Omi, through interactions with the Reaper-like motif and the BIR domain. cIAPs are reported to be cleaved by HtrA2/Omi.

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