金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: APAF-1 Long Name: Apoptotic Peptidase Activating Factor 1 Entrez Gene IDs: 317 (Human) Background: APAF-1 APAF-1, the human homolog of C. elegans CED-4, is a 130 kDa cytosolic protein that participates in the Cytochrome c-dependent activation of Caspase-3. The intrinsic Caspase activation pathway is activated by the release of mitochondrial Cytochrome c. This induces the cytosolic assembly of the apoptosome, a Caspase-activation complex involving Cytochrome c, APAF-1, and Caspase-9. Once activated, Caspase-9 can initiate a biochemical cascade involving activation of the downstream executioner Caspases-3, -6, and-7.