R&D Systems代理MAB923 Human Angiopoietin-1 MAb (Clone 171718) (500 UG)-试剂-金山科研平台

R&D Systems代理MAB923 Human Angiopoietin-1 MAb (Clone 171718) (500 UG)

2025-06-28

货号：MAB923

品牌：R&D Systems

规格：500 UG

目录价：￥4410.00

市场价格：￥3528.00

会员价格：￥3528.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Angiopoietin-1 Aliases: ANGPT1 Entrez Gene IDs: 284 (Human); 11600 (Mouse) Background: Angiopoietin-1

View Angiopoietin-1 IHC images. Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are two closely related secreted ligands which bind with similar affinity to Tie-2, a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 cDNA encodes a 498 amino acid (aa) residue precursor protein that contains a coiled-coiled domain near the amino-terminus and a fibrinogen-like domain at the C-terminus. Human Ang-1 shares approximately 97% and 60% amino acid sequence identity with mouse Ang-1 and human Ang-2, respectively. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.

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