R&D Systems代理PPS085 Phospho-Synaptotagmin (S309) Affinity Purified Polyclonal Ab (100 UL)-试剂-金山科研平台

R&D Systems代理PPS085 Phospho-Synaptotagmin (S309) Affinity Purified Polyclonal Ab (100 UL)

2025-06-27

货号：PPS085

品牌：R&D Systems

规格：100UL

目录价：￥5420.00

市场价格：￥4336.00

会员价格：￥4336.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Synaptotagmin-1 Aliases: P65; SVP65; SYT1 Entrez Gene IDs: 6857 (Human); 20979 (Mouse); 25716 (Rat) Background: Synaptotagmin

View Synaptotagmin IHC images.Synaptotagmins are integral membrane proteins of synaptic vesicles. Synaptotagmin-1 is a glycoprotein containing two C2 domains related to protein kinase C and sites for calcium-dependent binding of acidic phospholipids. Synaptotagmin-1 participates in the process of vesicular trafficking and exocytosis by inducing local calcium-dependent buckling of the plasma membrane. Synaptotagmin-2 is a single-pass, type Ia/III (no signal sequence) transmembrane (TM) glycoprotein. Synaptotagmin-2 is an integral component of neurotransmitter-containing synaptic vesicles that detects action potential-induced increases in presynaptic cytosolic calcium. Increased ionic calcium binds to synaptotagmin II at two sites (C2a and C2b) on its cytoplasmic tail. The first site also binds phospholipid, while the second site binds syntaxin. This promotes vesicle membrane fusion with the presynaptic plasma membrane, resulting in neurotransmitter release.

Synaptotagmins undergo three types of posttranslational modification that may affect function. N-linked glycosylation and/or O-linked glycosylation are likely necessary for recycling (internalization) of vesicle membrane after neurotransmitter release. Fatty acylation/palmitoylation of synaptotagmin may be necessary for proper cycling. Finally, synaptoagmin phosphorylation within the C2a site regulates calcium-binding, while phosphorylation in the C2b site may regulate calcium and syntaxin interaction.

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