货号：07-1800

品牌：Merck Millipore

规格：100UL

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-eIF4G Antibody | 07-1800 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects eIF4G at its N-terminal region. View All» Molecular Weight: 220 kDa View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to N-terminal region of human eIF4G. View All» Background Information: eIF4F is a translation initiation factor containing three subunits: eIF4A, eIF4E, and eIF4G. This complex is a key component in promoting ribosomal binding to the mRNA. eIF4G interacts with both eIF4A and eIF4E though its carboxy and amino terminal domains, respectively. eIF4E binds to the cap structure of the mRNA, while the ATP-dependent RNA helicase eIF4A unwinds the secondary structure of the 5’ UTR. eIF4G plays a critical role in coordinating the assembly of the eukaryotic initiation factors. It acts as a bridge to bind the cap-bound eIF4E, eIF4AI&II, the eIF3 complex, PABP1, and the kinase Mnk1 (Lejeune, F., et al., 2004) in a large eukaryotic initiation factor complex View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and Mouse. Not tested on other species. View All» Quality Assurance: Evaluated by western blot on HeLa cytoplasmic extract. Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect eIF4G in HeLa cytoplasmic extract and lysates from 293T and S10 cells. View All» Presentation: Rabbit polyclonal serum with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: Q04637 View All» Entrez Gene Number: NP_937884 View All» Gene Symbol:
  • EIF4-gamma

  • EIF4F

  • EIF4G

  • EIF4GI

  • eIF-4G1

  • p220
    View All» Alternate Names:
    • eIF-4-gamma 1

    • eIF-4G 1

    • eukaryotic translation initiation factor 4 gamma, 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunofluorescence
        View All» Entrez Gene Summary: The protein encoded by this gene is a component of the protein complex EIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.SUBUNIT STRUCTURE: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis. PTM: Phosphorylated at multiple sites in vivo. Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription. SEQUENCE SIMILARITIES: Belongs to the eIF4G family.Contains 1 MI domain.Contains 1 MIF4G domain.Contains 1 W2 domain.SEQUENCE CAUTION: The sequence BAA02185.1 differs from that shown. Reason: Frameshift at several positions. View All» Product Name: Anti-eIF4G Antibody | 07-1800 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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