货号：06-659

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-c-Jun (Ser73) Antibody | 06-659 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: This antibody detects phospho-c-Jun. May also detect phospho-JunD in properly treated cells since the sequence homology is identical (13/13). View All» Molecular Weight: ~40 kDa View All» Immunogen: BSA conjugated synthetic peptide (KLApSPELERLIIQC corresponding to amino acids 70-82 (pS73) of human c-Jun View All» Modifications: Phosphorylation View All» Background Information: c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress inducedsignaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun. View All» Species Reactivity:

• Bovine

• Human

• Mouse

• Rat

• Canine

• Chicken
  View All» Species Reactivity Note: Tested on human and mouse. Predicted to react with rat, bovine, canine and chicken based on sequence homology. View All» Application Notes: Western Blot Analysis : A previous lot of this antibody detected 10 ng of phosphorylated gst-Jun, but did not detect 10 ng of nonphosphorylated Jun, as reported by an independent laboratory. View All» Control: Untreated and anisomycin-treated NIH/3T3 cell lysate. View All» Quality Assurance: Evaluated by western blot on untreated and anisomycin-treated NIH/3T3 cell lysate.Western Blot Analysis: 1:500-1:1000 dilution of this antibody detected phosphor-c-Jun (Ser73) in untreated and anisomycin-treated NIH/3T3 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Maintain for 1 year at 2 to 8°C from date of shipment. View All» UniProt Number: P05412 View All» Entrez Gene Number: NP_002219.1 View All» Gene Symbol:
  • JUN

  • p39

  • AP1

  • c-Jun
    View All» Alternate Names:
    • Activator protein 1

    • Jun activation domain binding protein

    • Proto-oncogene c-jun

    • V-jun avian sarcoma virus 17 oncogene homolog

    • enhancer-binding protein AP1

    • jun oncogene

    • v-jun sarcoma virus 17 oncogene homolog

    • v-jun sarcoma virus 17 oncogene homolog (avian)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. View All» UniProt Summary: FUNCTION: SwissProt: P05412 # Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.SIZE: 331 amino acids; 35676 Da SUBUNIT: Interacts with FOS to form a dimer. Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.SUBCELLULAR LOCATION: Nucleus.PTM: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.SIMILARITY: SwissProt: P05412 ## Belongs to the bZIP family. Jun subfamily. & Contains 1 bZIP domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-c-Jun (Ser73) View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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